Cancer imaging
Bioxydyn provides advanced functional MRI biomarkers in oncology, using techniques such as diffusion MRI and dynamic contrast-enhanced (DCE) MRI, and is the leading CRO offering tumor hypoxia imaging to inform therapy effectiveness or characterise tumour physiology.
OE-MRI
We are world-leading in the use of Oxygen-enhanced MRI (OE-MRI), which can be applied to monitor the delivery of oxygen to tumours. This is of particular utility, as tumour oxygenation levels are known to impact on disease progression and on response to therapy. Our method for identifying and imaging tumour hypoxia has been shown to be sensitive to drug and radiotherapy effects. Bioxydyn personnel lead the field in developing and deploying OE-MRI.
DCE-MRI
Dynamic contrast-enhanced MRI (DCE-MRI) is recognised by the Quantitative Imaging Biomarkers Alliance (QIBA) as a functional imaging biomarker of angiogenesis and vascular function in cancer. Bioxydyn personnel bring decades of experience to the study of cancer using DCE-MRI.
HP MRI
Bioxydyn partners with NVision Imaging Technologies to advance quantitative metabolic imaging in oncology. By combining NVision’s hyperpolarized metabolic imaging agents with Bioxydyn’s quantitative imaging biomarker expertise, we enable real-time, in vivo assessment of tumour metabolism.
This collaboration supports translational continuity from preclinical studies to early-phase clinical trials, helping sponsors generate robust pharmacodynamic insights and reduce development risk.
Diffusion MRI
Diffusion MRI (apparent diffusion coefficient, ADC) detects changes in water diffusion, which is a sensitive marker for cancer. These changes are typically associated with the earliest stages of biological response to treatment and so can act as early markers of the influence of intervention.
