Oxygen-enhanced MRI and multiple breath washout with Short extension reveal cystic fibrosis lung disease progression despite triple modulator therapy

Short, Christopher; Semple, Tom; Abkir, Mary; et al.

Thorax • 2026-06-03

Assessing Drug-mediated Inhibition of Liver Transporter Function with MRI: A First-in-Human Study

Min, Thazin; Tibiletti, Marta; Hockings, Paul D.; et al.

Radiology • 2025-12-01

Why it matters: First demonstration of a practical approach in humans for measuring drug-mediated inhibution of liver function using gadoxetate-enhanced MRI

Ultra-fast MRI for dementia diagnosis and treatment eligibility: A prospective study

Miguel Rosa‐Grilo, Haroon R Chughtai, David L Thomas, Daniel C Alexander, Millie Beament, Christopher RS Belder, H Rolf Jäger, Emma A Lim, Nicholas Magill, Dermot Mallon, Jennifer M Nicholas, Owen Nicholas, Floey Urban, Geoff JM Parker, Frederik Barkhof, Catherine J Mummery, Nick C Fox

Alzheimer's & Dementia • 2025

Why it matters: First demonstration of the diagnostic potential of ultra-fast MRI protocols for dementia diagnosis

T2*-weighted oxygen-enhanced pulmonary MRI in COPD is linked to resting and exertional functional measurements

Amany F Elbehairy, Josephine H Naish, Hossein Baghertash, Geoff JM Parker, Christopher A Miller, Jørgen Vestbo, Alex R Horsley

BMJ Open Respiratory Research • 2025

Why it matters: First demonstration of Bioxydyn's dual echo T2*-weighted imaging protocol applied in COPD

Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action

O’Connor, James P.B.; Tessyman, Victoria; Little, Ross A.; et al.

Cancer Research Communications • 2024-10-01

Why it matters: First demonstration of the use of OE-MRI in monitoring action of hypoxia targetting therapies in cancer

Contrast enhanced longitudinal changes observed in an experimental bleomycin-induced lung fibrosis rat model by radial DCE-MRI at 9.4T

in ‘t Zandt, René; Mahmutovic Persson, Irma; Tibiletti, Marta; et al.

PLOS ONE • 2024-09-27

Why it matters: Demonstrating the role of DCE-MRI in fibrosis via a bleomycin model, indicating its use as a potenital PD marker in ILD

Feasibility of dynamic T2*‐based oxygen‐enhanced lung MRI at 3T

Kim, Mina; Naish, Josephine H.; Needleman, Sarah H.; et al.

Magnetic Resonance in Medicine • 2024-03

Why it matters: Demonstration of Bioxydyn's T2*-sensitive OE-MRI protocol at 3T, extending the viable use of OE-MRI to this field strength

Filter exchange imaging with crusher gradient modelling detects increased blood–brain barrier water permeability in response to mild lung infection

Ohene, Yolanda; Harris, William J.; Powell, Elizabeth; et al.

Fluids and Barriers of the CNS • 2023-04-03

Why it matters: First demonstration using MRI of the role of systemic infection on blood-brain barrier function, highlighting the links between systemic and neuro-inflammation

Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug–Drug Interactions in Rats

Melillo, Nicola; Scotcher, Daniel; Kenna, J. Gerry; et al.

Pharmaceutics • 2023-03-10

Why it matters: Strong drug-safety translation linking in vivo imaging with PBK modelling to predict hepatic transporter-mediated DDIs.

MRI of the joint and evaluation of the granulocyte–macrophage colony-stimulating factor–CCL17 axis in patients with rheumatoid arthritis receiving otilimab: a phase 2a randomised mechanistic study

Genovese, Mark C; Berkowitz, Mario; Conaghan, Philip G; et al.

The Lancet Rheumatology • 2020-11

Why it matters: Mechanistic clinical trial connecting MRI readouts with GM-CSF/CCL17 biology in rheumatoid arthritis.

Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Salem, Ahmed; Little, Ross A.; Latif, Ayşe; et al.

Clinical Cancer Research • 2019-07-01

Why it matters: Translational paper showing oxygen-enhanced MRI is feasible and repeatable in NSCLC and sensitive to radiotherapy-related hypoxia change.

Imaging biomarker roadmap for cancer studies

O'Connor, James P. B.; Aboagye, Eric O.; Adams, Judith E.; et al.

Nature Reviews Clinical Oncology • 2017-03

Why it matters: Widely cited roadmap that helped define how imaging biomarkers should be qualified and deployed in cancer studies.