Imaging Biomarker Services

Bioxydyn provides high-standard, quantitative MRI imaging services to the pharmaceutical industry and for clinical/academic R&D in small or large multi-centre studies.

Bioxydyn’s accurate, reliable imaging biomarkers are based on scientifically leading techniques and efficient, high-quality imaging study management processes. Bioxydyn gives unique insight into disease progression and drug effects, helps pharmaceutical companies make investment decisions and assists clinicians in developing the best treatment for patients.

Imaging Biomarker Services

Bioxydyn provides high-standard, quantitative MRI imaging services to the pharmaceutical industry and for clinical/academic R&D in small or large multi-centre studies.

Bioxydyn’s accurate, reliable imaging biomarkers are based on scientifically leading techniques and efficient, high-quality imaging study management processes. Bioxydyn gives unique insight into disease progression and drug effects, helps pharmaceutical companies make investment decisions and assists clinicians in developing the best treatment for patients.

Cancer imaging

Bioxydyn provides advanced functional MRI biomarkers in oncology, using techniques such as diffusion MRI and dynamic contrast-enhanced (DCE) MRI, and is the leading CRO offering tumor hypoxia imaging to inform therapy effectiveness or characterise tumour physiology.

Our technologies allow for the assessment of cancer physiology, such as tumour microscructure, vascularization and oxygenation, that in turn supports the evaluation of disease progression and early treatment effects.

Respiratory function imaging

Bioxydyn offers imaging biomarkers in respiratory diseases such as pulmonary embolism, asthma, pulmonary hypertension, interstitial disease and COPD. We are the world leaders in delivering oxygen-enhanced MRI (OE-MRI) for imaging lung function. OE-MRI uses oxygen as an MR imaging agent and can be simply and economically deployed on most hospital scanners.

Bioxydyn's cutting-edge dynamic contrast-enhanced MRI technologies provide information on lung perfusion and other microvascular function including endothelial permeability and leakage space.

We also provide non-contrast imaging biomarkers of lung ventilation based on the motion of the lung over time. These measurements provide ventilation-weighted imaging in a short scan without administration of gases or contrast agents.

Inflammation

Bioxydyn has delivered multiple studies for pharmaceutical companies in the quantitative imaging of inflammation in a wide range of diseases, including rheumatoid arthritis and osteoarthritis. We use dynamic contrast-enhanced MRI (DCE-MRI) to quantify changes in perfusion and endothelial integrity in the presence of inflammation and during treatment. Bioxydyn has defined many of the standard approaches to the technique’s implementation in clinical trials.

Bioxydyn uses quantitative biomarkers based on sound and widely accepted science that are extremely sensitive to drug effects, only require small patient numbers and can be easily deployed in most clinical settings.

Neuroimaging

Bioxydyn is experienced in the deployment of quantitative MRI methods for neuroscience. We provide both commonly-used techniques, such as atrophy measurement and diffusion MRI, and more complex methods, most often seen in academic studies, such as dynamic contrast-enhanced MRI (DCE-MRI) measures of subtle blood brain barrier dysfunction, MR spectroscopy, MR relaxometry and anatomical connectivity mapping.

These measurements can be used to interrogate physiological phenomena, metabolism, drug effects and mechanisms of action in conditions including stroke, neurodevelopmental conditions, multiple sclerosis, dementia and neuro-oncology.

Bioxydyn's service approach


Innovative study design

Bioxydyn helps design studies and flexibly adapts its tools to the requirements of new studies and techniques.

Site set-up and qualification

Bioxydyn can establish the sponsor’s choice of sites to the study and provides on-site or remote training to ensure high quality image acquisition.

Image quality control

Bioxydyn checks images as they arrive and feeds back to the site so that high quality acquisition and calibration is maintained.

Analysis

Using VoxelFlow, a proprietary in-house analysis and study management platform, Bioxydyn produces biomarker measurements that are reliable, repeatable and auditable.

Comprehensive reporting

Bioxydyn returns data, processed images and, where requested, scientific interpretation according to customer requirements.

A global reach

Bioxydyn trains and works with any imaging site defined by the customer following a simple electronic qualification process. Most globally installed MRI equipment can be set up to perform our quantitative methods, but Bioxydyn can provide quick and accurate assurance.

Whatever the study protocol, Bioxydyn can work with your preferred imaging sites, or suggest alternatives.


Over a decade of reliable service provision

Founded in 2009, Bioxydyn has a strong track record in the delivery of imaging services in clinical trials.

Bioxydyn has delivered numerous studies for multiple pharma/biotech and clinical/academic clients. Bioxydyn also has a strong track record in supporting, winning and delivering grant funded studies.

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