Bioxydyn is experienced in the deployment of quantitative MRI methods for neuroscience in conditions including stroke, multiple sclerosis, neurodevelopmental conditions, dementia and neuro-oncology.
We provide commonly-used techniques such as atrophy measurements and diffusion MRI measurements. We also provide methods more commonly seen in academic studies due to their complexity, including dynamic contrast-enhanced MRI (DCE-MRI) measurements of subtle blood brain barrier dysfunction, MR Spectroscopy, relaxometry, and Anatomical Connectivity Mapping.
These measurements can be used to interrogate physiological phenomena, metabolism, drug effects and mechanisms of action in a wide range of neurological conditions.
Jandric D, Lipp I, Paling D, Rog D, Castellazzi G, Haroon H, Parkes L, Parker GJM, Tomassini V, Muhlert N, Mechanisms of Network Changes in Cognitive Impairment in Multiple Sclerosis. Neurology. 2021 Nov 9;97(19):e1886-e1897.
Kerkelä L, Nery F, Callaghan R, Zhou F, Gyori NG, Szczepankiewicz F, Palombo M, Parker GJM, Zhang H, Hall MG, Clark CA, Comparative analysis of signal models for microscopic fractional anisotropy estimation using q-space trajectory encoding. Neuroimage. 2021 Nov 15;242:118445.
McFadden JJ, Matthews JC, Scott LA, Parker GJM, Lohézic M, Parkes LM, Optimization of quantitative susceptibility mapping for regional estimation of oxygen extraction fraction in the brain. Magn Reson Med. 2021 Sep;86(3):1314-1329.
Dickie BR, Boutin H, Parker GJM, Parkes LM, Alzheimer's disease pathology is associated with earlier alterations to blood-brain barrier water permeability compared with healthy ageing in TgF344-AD rats. NMR Biomed. 2021 Jul;34(7):e4510.
Al-Bachari S, Naish JH, Parker GJM, Emsley HCA, Parkes LM, Blood-Brain Barrier Leakage Is Increased in Parkinson's Disease. Front Physiol. 2020;11:593026.
Scott LA, Dickie BR, Rawson SD, Coutts G, Burnett TL, Allan SM, Parker GJ, Parkes LM, Characterisation of microvessel blood velocity and segment length in the brain using multi-diffusion-time diffusion-weighted MRI. J Cereb Blood Flow Metab. 2021 Aug;41(8):1939-1953.
Dickie BR, Parker GJM, Parkes LM, Measuring water exchange across the blood-brain barrier using MRI. Prog Nucl Magn Reson Spectrosc. 2020 Feb;116:19-39.
Bajada CJ, Trujillo-Barreto NJ, Parker GJM, Cloutman LL, Lambon Ralph MA, A structural connectivity convergence zone in the ventral and anterior temporal lobes: Data-driven evidence from structural imaging. Cortex. 2019 Nov;120:298-307.
Lundell H, Nilsson M, Dyrby TB, Parker GJM, Cristinacce PLH, Zhou FL, Topgaard D, Lasič S, Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail. Sci Rep. 2019 Jun 21;9(1):9026.
Riemer F, McHugh D, Zaccagna F, Lewis D, McLean MA, Graves MJ, Gilbert FJ, Parker GJM, Gallagher FA, Measuring tissue sodium concentration: Cross-vendor repeatability and reproducibility of 23Na-MRI across two sites. J Magn Reson Imaging. 2019 Oct;50(4):1278-1284.
Whitley CB, Vijay S, Yao B, Pineda M, Parker GJM, Rojas-Caro S, Zhang X, Dai Y, Cinar A, Bubb G, Patki KC, Escolar ML, Final results of the phase 1/2, open-label clinical study of intravenous recombinant human N-acetyl-α-d-glucosaminidase (SBC-103) in children with mucopolysaccharidosis IIIB. Mol Genet Metab. 2019 Feb;126(2):131-138.
Busby N, Halai AD, Parker GJM, Coope DJ, Lambon Ralph MA, Mapping whole brain connectivity changes: The potential impact of different surgical resection approaches for temporal lobe epilepsy. Cortex. 2019 Apr;113:1-14.
Dickie BR, Vandesquille M, Ulloa J, Boutin H, Parkes LM, Parker GJM, Water-exchange MRI detects subtle blood-brain barrier breakdown in Alzheimer's disease rats. Neuroimage. 2019 Jan 1;184:349-358.
Grech-Sollars M, Zhou FL, Waldman AD, Parker GJM, Hubbard Cristinacce PL, Stability and reproducibility of co-electrospun brain-mimicking phantoms for quality assurance of diffusion MRI sequences. Neuroimage. 2018 Nov 1;181:395-402.
Abid KA, Sobowale OA, Parkes LM, Naish J, Parker GJM, du Plessis D, Brough D, Barrington J, Allan SM, Hinz R, Parry-Jones AR, Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI. J Neuroimaging. 2018 Mar;28(2):158-161.
Bajada CJ, Haroon HA, Azadbakht H, Parker GJM, Lambon Ralph MA, Cloutman LL, The tract terminations in the temporal lobe: Their location and associated functions. Cortex. 2017 Dec;97:277-290.
Lyksborg M, Siebner HR, Sørensen PS, Blinkenberg M, Parker GJ, Dogonowski AM, Garde E, Larsen R, Dyrby TB, Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity. PLoS One. 2014;9(4):e95540.
Bozzali M, Spanò B, Parker GJ, Giulietti G, Castelli M, Basile B, Rossi S, Serra L, Magnani G, Nocentini U, Caltagirone C, Centonze D, Cercignani M, Anatomical brain connectivity can assess cognitive dysfunction in multiple sclerosis. Mult Scler. 2013 Aug;19(9):1161-8.
Bozzali M, Parker GJ, Spanò B, Serra L, Giulietti G, Perri R, Magnani G, Marra C, G Vita M, Caltagirone C, Cercignani M, Brain tissue modifications induced by cholinergic therapy in Alzheimer's disease. Hum Brain Mapp. 2013 Dec;34(12):3158-67.