Bioxydyn is experienced in the deployment of quantitative MRI methods for neuroscience in conditions including stroke, multiple sclerosis, neurodevelopmental conditions, dementia and neuro-oncology.
We provide commonly-used techniques such as atrophy measurements and diffusion MRI measurements. We also provide methods more commonly seen in academic studies due to their complexity, including dynamic contrast-enhanced MRI (DCE-MRI) measurements of subtle blood brain barrier dysfunction, MR Spectroscopy, relaxometry, and Anatomical Connectivity Mapping.
These measurements can be used to interrogate physiological phenomena, metabolism, drug effects and mechanisms of action in a wide range of neurological conditions.
Dickie BR, Vandesquille M, Ulloa J, Boutin H, Parkes LM, Parker GJM, Water-exchange MRI detects subtle blood-brain barrier breakdown in Alzheimer's disease rats. Neuroimage. 2019 Jan 1;184:349-358.
Dickie BR, Parker GJM, Parkes LM, Measuring water exchange across the blood-brain barrier using MRI. Prog Nucl Magn Reson Spectrosc. 2020 Feb;116:19-39.
Bajada CJ, Trujillo-Barreto NJ, Parker GJM, Cloutman LL, Lambon Ralph MA, A structural connectivity convergence zone in the ventral and anterior temporal lobes: Data-driven evidence from structural imaging. Cortex. 2019 Nov;120:298-307.
Riemer F, McHugh D, Zaccagna F, Lewis D, McLean MA, Graves MJ, Gilbert FJ, Parker GJM, Gallagher FA, Measuring tissue sodium concentration: Cross-vendor repeatability and reproducibility of 23Na-MRI across two sites. J Magn Reson Imaging. 2019 Oct;50(4):1278-1284.
Lundell H, Nilsson M, Dyrby TB, Parker GJM, Cristinacce PLH, Zhou FL, Topgaard D, Lasič S, Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail. Sci Rep. 2019 Jun 21;9(1):9026.
Busby N, Halai AD, Parker GJM, Coope DJ, Lambon Ralph MA, Mapping whole brain connectivity changes: The potential impact of different surgical resection approaches for temporal lobe epilepsy. Cortex. 2019 Apr;113:1-14.
Whitley CB, Vijay S, Yao B, Pineda M, Parker GJM, Rojas-Caro S, Zhang X, Dai Y, Cinar A, Bubb G, Patki KC, Escolar ML, Final results of the phase 1/2, open-label clinical study of intravenous recombinant human N-acetyl-α-d-glucosaminidase (SBC-103) in children with mucopolysaccharidosis IIIB. Mol Genet Metab. 2019 Feb;126(2):131-138.
Grech-Sollars M, Zhou FL, Waldman AD, Parker GJM, Hubbard Cristinacce PL, Stability and reproducibility of co-electrospun brain-mimicking phantoms for quality assurance of diffusion MRI sequences. Neuroimage. 2018 Nov 1;181:395-402.
Abid KA, Sobowale OA, Parkes LM, Naish J, Parker GJM, du Plessis D, Brough D, Barrington J, Allan SM, Hinz R, Parry-Jones AR, Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI. J Neuroimaging. 2018 Mar;28(2):158-161.
Bajada CJ, Haroon HA, Azadbakht H, Parker GJM, Lambon Ralph MA, Cloutman LL, The tract terminations in the temporal lobe: Their location and associated functions. Cortex. 2017 Dec;97:277-290.
Lyksborg M, Siebner HR, Sørensen PS, Blinkenberg M, Parker GJ, Dogonowski AM, Garde E, Larsen R, Dyrby TB, Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity. PLoS One. 2014;9(4):e95540.
Bozzali M, Parker GJ, Spanò B, Serra L, Giulietti G, Perri R, Magnani G, Marra C, G Vita M, Caltagirone C, Cercignani M, Brain tissue modifications induced by cholinergic therapy in Alzheimer's disease. Hum Brain Mapp. 2013 Dec;34(12):3158-67.
Bozzali M, Spanò B, Parker GJ, Giulietti G, Castelli M, Basile B, Rossi S, Serra L, Magnani G, Nocentini U, Caltagirone C, Centonze D, Cercignani M, Anatomical brain connectivity can assess cognitive dysfunction in multiple sclerosis. Mult Scler. 2013 Aug;19(9):1161-8.