Bioxydyn is experienced in the deployment of quantitative MRI methods for neuroscience in conditions including stroke, multiple sclerosis, neurodevelopmental conditions, dementia and neuro-oncology. Our collaboration with Queen Square Analytics enables advanced AI methods for patient stratification with a focus on multiple sclerosis and Alzheimer's disease.
We provide commonly-used techniques such as atrophy measurements and diffusion MRI measurements. We also provide methods more commonly seen in academic studies due to their complexity, including dynamic contrast-enhanced MRI (DCE-MRI) measurements of subtle blood brain barrier dysfunction, MR Spectroscopy, relaxometry, and Anatomical Connectivity Mapping.
These measurements can be used to interrogate physiological phenomena, metabolism, drug effects and mechanisms of action in a wide range of neurological conditions.
Canales-Rodríguez EJ, Pizzolato M, Zhou FL, Barakovic M, Thiran JP, Jones DK, Parker GJM, Dyrby TB, Pore size estimation in axon-mimicking microfibers with diffusion-relaxation MRI. Magn Reson Med. 2024 Jun;91(6):2579-2596.
Ravi D, Alzheimer’s Disease Neuroimaging Initiative, Barkhof F, Alexander DC, Puglisi L, Parker GJM, Eshaghi A, An efficient semi-supervised quality control system trained using physics-based MRI-artefact generators and adversarial training. Med Image Anal. 2024 Jan;91:103033.
Powell E, Dickie BR, Ohene Y, Maskery M, Parker GJM, Parkes LM, Blood-brain barrier water exchange measurements using contrast-enhanced ASL. NMR Biomed. 2023 Nov;36(11):e5009.
Ohene Y, Harris WJ, Powell E, Wycech NW, Smethers KF, Lasič S, South K, Coutts G, Sharp A, Lawrence CB, Boutin H, Parker GJM, Parkes LM, Dickie BR, Filter exchange imaging with crusher gradient modelling detects increased blood-brain barrier water permeability in response to mild lung infection. Fluids Barriers CNS. 2023 Apr 3;20(1):25.
Powell E, Ohene Y, Battiston M, Dickie BR, Parkes LM, Parker GJM, Blood-brain barrier water exchange measurements using FEXI: Impact of modeling paradigm and relaxation time effects. Magn Reson Med. 2023 Jul;90(1):34-50.
Dickie BR, Jin T, Wang P, Hinz R, Harris W, Boutin H, Parker GJ, Parkes LM, Matthews JC, Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI. J Cereb Blood Flow Metab. 2022 Nov;42(11):2066-2079.
Dickie BR, Parker GJM, Parkes LM, Measuring water exchange across the blood-brain barrier using MRI. Prog Nucl Magn Reson Spectrosc. 2020 Feb;116:19-39.
Bajada CJ, Trujillo-Barreto NJ, Parker GJM, Cloutman LL, Lambon Ralph MA, A structural connectivity convergence zone in the ventral and anterior temporal lobes: Data-driven evidence from structural imaging. Cortex. 2019 Nov;120:298-307.
Lundell H, Nilsson M, Dyrby TB, Parker GJM, Cristinacce PLH, Zhou FL, Topgaard D, Lasič S, Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail. Sci Rep. 2019 Jun 21;9(1):9026.
Riemer F, McHugh D, Zaccagna F, Lewis D, McLean MA, Graves MJ, Gilbert FJ, Parker GJM, Gallagher FA, Measuring tissue sodium concentration: Cross-vendor repeatability and reproducibility of 23Na-MRI across two sites. J Magn Reson Imaging. 2019 Oct;50(4):1278-1284.
Whitley CB, Vijay S, Yao B, Pineda M, Parker GJM, Rojas-Caro S, Zhang X, Dai Y, Cinar A, Bubb G, Patki KC, Escolar ML, Final results of the phase 1/2, open-label clinical study of intravenous recombinant human N-acetyl-α-d-glucosaminidase (SBC-103) in children with mucopolysaccharidosis IIIB. Mol Genet Metab. 2019 Feb;126(2):131-138.
Busby N, Halai AD, Parker GJM, Coope DJ, Lambon Ralph MA, Mapping whole brain connectivity changes: The potential impact of different surgical resection approaches for temporal lobe epilepsy. Cortex. 2019 Apr;113:1-14.
Dickie BR, Vandesquille M, Ulloa J, Boutin H, Parkes LM, Parker GJM, Water-exchange MRI detects subtle blood-brain barrier breakdown in Alzheimer's disease rats. Neuroimage. 2019 Jan 1;184:349-358.
Grech-Sollars M, Zhou FL, Waldman AD, Parker GJM, Hubbard Cristinacce PL, Stability and reproducibility of co-electrospun brain-mimicking phantoms for quality assurance of diffusion MRI sequences. Neuroimage. 2018 Nov 1;181:395-402.
Abid KA, Sobowale OA, Parkes LM, Naish J, Parker GJM, du Plessis D, Brough D, Barrington J, Allan SM, Hinz R, Parry-Jones AR, Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI. J Neuroimaging. 2018 Mar;28(2):158-161.
Bajada CJ, Haroon HA, Azadbakht H, Parker GJM, Lambon Ralph MA, Cloutman LL, The tract terminations in the temporal lobe: Their location and associated functions. Cortex. 2017 Dec;97:277-290.
Lyksborg M, Siebner HR, Sørensen PS, Blinkenberg M, Parker GJ, Dogonowski AM, Garde E, Larsen R, Dyrby TB, Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity. PLoS One. 2014;9(4):e95540.
Bozzali M, Spanò B, Parker GJ, Giulietti G, Castelli M, Basile B, Rossi S, Serra L, Magnani G, Nocentini U, Caltagirone C, Centonze D, Cercignani M, Anatomical brain connectivity can assess cognitive dysfunction in multiple sclerosis. Mult Scler. 2013 Aug;19(9):1161-8.
Bozzali M, Parker GJ, Spanò B, Serra L, Giulietti G, Perri R, Magnani G, Marra C, G Vita M, Caltagirone C, Cercignani M, Brain tissue modifications induced by cholinergic therapy in Alzheimer's disease. Hum Brain Mapp. 2013 Dec;34(12):3158-67.
