Bioxydyn is experienced in the deployment of quantitative MRI methods for neuroscience in conditions including multiple sclerosis, neurodevelopmental conditions, dementia and neuro-oncology. Our collaboration with Queen Square Analytics enables advanced AI methods for patient stratification with a focus on multiple sclerosis and Alzheimer's disease.
Bioxydyn provides commonly-used techniques such as atrophy measurements and diffusion MRI measurements. We also provide more complex quantitative methods, including dynamic contrast-enhanced MRI (DCE-MRI) measurements of subtle blood brain barrier dysfunction, arterial spin labelling (ASL), MR Spectroscopy, and relaxometry. These measurements can be used to interrogate physiological phenomena, metabolism, drug effects and mechanism of action in a wide range of neurological conditions.
Thomson EL, Powell E, Gandini Wheeler-Kingshott CAM, Parker GJM, Quantification of water exchange across the blood-brain barrier using noncontrast MR fingerprinting. Magn Reson Med. 2024 Oct;92(4):1392-1403.
Woods JG, Achten E, Asllani I, Bolar DS, Dai W, Detre JA, Fan AP, Fernández-Seara MA, Golay X, Günther M, Guo J, Hernandez-Garcia L, Ho ML, Juttukonda MR, Lu H, MacIntosh BJ, Madhuranthakam AJ, Mutsaerts HJ, Okell TW, Parkes LM, Pinter N, Pinto J, Qin Q, Smits M, Suzuki Y, Thomas DL, Van Osch MJP, Wang DJJ, Warnert EAH, Zaharchuk G, Zelaya F, Zhao M, Chappell MA, ISMRM Perfusion Study Group, Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: Acquisition, quantification, and clinical applications. Magn Reson Med. 2024 Aug;92(2):469-495.
Canales-Rodríguez EJ, Pizzolato M, Zhou FL, Barakovic M, Thiran JP, Jones DK, Parker GJM, Dyrby TB, Pore size estimation in axon-mimicking microfibers with diffusion-relaxation MRI. Magn Reson Med. 2024 Jun;91(6):2579-2596.
Ravi D, Alzheimer’s Disease Neuroimaging Initiative, Barkhof F, Alexander DC, Puglisi L, Parker GJM, Eshaghi A, An efficient semi-supervised quality control system trained using physics-based MRI-artefact generators and adversarial training. Med Image Anal. 2024 Jan;91:103033.
Powell E, Dickie BR, Ohene Y, Maskery M, Parker GJM, Parkes LM, Blood-brain barrier water exchange measurements using contrast-enhanced ASL. NMR Biomed. 2023 Nov;36(11):e5009.
Ohene Y, Harris WJ, Powell E, Wycech NW, Smethers KF, Lasič S, South K, Coutts G, Sharp A, Lawrence CB, Boutin H, Parker GJM, Parkes LM, Dickie BR, Filter exchange imaging with crusher gradient modelling detects increased blood-brain barrier water permeability in response to mild lung infection. Fluids Barriers CNS. 2023 Apr 3;20(1):25.
Powell E, Ohene Y, Battiston M, Dickie BR, Parkes LM, Parker GJM, Blood-brain barrier water exchange measurements using FEXI: Impact of modeling paradigm and relaxation time effects. Magn Reson Med. 2023 Jul;90(1):34-50.
Wang X, Bishop C, O'Callaghan J, Gayhoor A, Albani J, Theriault W, Chappell M, Golay X, Wang D, Becerra L, MRI assessment of cerebral perfusion in clinical trials. Drug Discov Today. 2023 Apr;28(4):103506.
Dickie BR, Jin T, Wang P, Hinz R, Harris W, Boutin H, Parker GJ, Parkes LM, Matthews JC, Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI. J Cereb Blood Flow Metab. 2022 Nov;42(11):2066-2079.
Jandric D, Parker GJM, Haroon H, Tomassini V, Muhlert N, Lipp I, A tractometry principal component analysis of white matter tract network structure and relationships with cognitive function in relapsing-remitting multiple sclerosis. Neuroimage Clin. 2022;34:102995.
Jandric D, Lipp I, Paling D, Rog D, Castellazzi G, Haroon H, Parkes L, Parker GJM, Tomassini V, Muhlert N, Mechanisms of Network Changes in Cognitive Impairment in Multiple Sclerosis. Neurology. 2021 Nov 9;97(19):e1886-e1897.
Kerkelä L, Nery F, Callaghan R, Zhou F, Gyori NG, Szczepankiewicz F, Palombo M, Parker GJM, Zhang H, Hall MG, Clark CA, Comparative analysis of signal models for microscopic fractional anisotropy estimation using q-space trajectory encoding. Neuroimage. 2021 Nov 15;242:118445.
Manning C, Stringer M, Dickie B, Clancy U, Valdés Hernandez MC, Wiseman SJ, Garcia DJ, Sakka E, Backes WH, Ingrisch M, Chappell F, Doubal F, Buckley C, Parkes LM, Parker GJM, Marshall I, Wardlaw JM, Thrippleton MJ, Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage. Magn Reson Med. 2021 Oct;86(4):1888-1903.
McFadden JJ, Matthews JC, Scott LA, Parker GJM, Lohézic M, Parkes LM, Optimization of quantitative susceptibility mapping for regional estimation of oxygen extraction fraction in the brain. Magn Reson Med. 2021 Sep;86(3):1314-1329.
Dickie BR, Boutin H, Parker GJM, Parkes LM, Alzheimer's disease pathology is associated with earlier alterations to blood-brain barrier water permeability compared with healthy ageing in TgF344-AD rats. NMR Biomed. 2021 Jul;34(7):e4510.
Scott LA, Dickie BR, Rawson SD, Coutts G, Burnett TL, Allan SM, Parker GJ, Parkes LM, Characterisation of microvessel blood velocity and segment length in the brain using multi-diffusion-time diffusion-weighted MRI. J Cereb Blood Flow Metab. 2021 Aug;41(8):1939-1953.
Dickie BR, Parker GJM, Parkes LM, Measuring water exchange across the blood-brain barrier using MRI. Prog Nucl Magn Reson Spectrosc. 2020 Feb;116:19-39.
Bajada CJ, Trujillo-Barreto NJ, Parker GJM, Cloutman LL, Lambon Ralph MA, A structural connectivity convergence zone in the ventral and anterior temporal lobes: Data-driven evidence from structural imaging. Cortex. 2019 Nov;120:298-307.
Lundell H, Nilsson M, Dyrby TB, Parker GJM, Cristinacce PLH, Zhou FL, Topgaard D, Lasič S, Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail. Sci Rep. 2019 Jun 21;9(1):9026.
Riemer F, McHugh D, Zaccagna F, Lewis D, McLean MA, Graves MJ, Gilbert FJ, Parker GJM, Gallagher FA, Measuring tissue sodium concentration: Cross-vendor repeatability and reproducibility of 23Na-MRI across two sites. J Magn Reson Imaging. 2019 Oct;50(4):1278-1284.
Whitley CB, Vijay S, Yao B, Pineda M, Parker GJM, Rojas-Caro S, Zhang X, Dai Y, Cinar A, Bubb G, Patki KC, Escolar ML, Final results of the phase 1/2, open-label clinical study of intravenous recombinant human N-acetyl-α-d-glucosaminidase (SBC-103) in children with mucopolysaccharidosis IIIB. Mol Genet Metab. 2019 Feb;126(2):131-138.
Busby N, Halai AD, Parker GJM, Coope DJ, Lambon Ralph MA, Mapping whole brain connectivity changes: The potential impact of different surgical resection approaches for temporal lobe epilepsy. Cortex. 2019 Apr;113:1-14.
Dickie BR, Vandesquille M, Ulloa J, Boutin H, Parkes LM, Parker GJM, Water-exchange MRI detects subtle blood-brain barrier breakdown in Alzheimer's disease rats. Neuroimage. 2019 Jan 1;184:349-358.
Grech-Sollars M, Zhou FL, Waldman AD, Parker GJM, Hubbard Cristinacce PL, Stability and reproducibility of co-electrospun brain-mimicking phantoms for quality assurance of diffusion MRI sequences. Neuroimage. 2018 Nov 1;181:395-402.
Abid KA, Sobowale OA, Parkes LM, Naish J, Parker GJM, du Plessis D, Brough D, Barrington J, Allan SM, Hinz R, Parry-Jones AR, Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI. J Neuroimaging. 2018 Mar;28(2):158-161.
Haller S, Zaharchuk G, Thomas DL, Lovblad KO, Barkhof F, Golay X, Arterial Spin Labeling Perfusion of the Brain: Emerging Clinical Applications. Radiology. 2016 Nov;281(2):337-356.
Bajada CJ, Haroon HA, Azadbakht H, Parker GJM, Lambon Ralph MA, Cloutman LL, The tract terminations in the temporal lobe: Their location and associated functions. Cortex. 2017 Dec;97:277-290.
Lyksborg M, Siebner HR, Sørensen PS, Blinkenberg M, Parker GJ, Dogonowski AM, Garde E, Larsen R, Dyrby TB, Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity. PLoS One. 2014;9(4):e95540.
Alsop DC, Detre JA, Golay X, Günther M, Hendrikse J, Hernandez-Garcia L, Lu H, MacIntosh BJ, Parkes LM, Smits M, van Osch MJ, Wang DJ, Wong EC, Zaharchuk G, Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med. 2015 Jan;73(1):102-16.
Bozzali M, Spanò B, Parker GJ, Giulietti G, Castelli M, Basile B, Rossi S, Serra L, Magnani G, Nocentini U, Caltagirone C, Centonze D, Cercignani M, Anatomical brain connectivity can assess cognitive dysfunction in multiple sclerosis. Mult Scler. 2013 Aug;19(9):1161-8.
Bozzali M, Parker GJ, Spanò B, Serra L, Giulietti G, Perri R, Magnani G, Marra C, G Vita M, Caltagirone C, Cercignani M, Brain tissue modifications induced by cholinergic therapy in Alzheimer's disease. Hum Brain Mapp. 2013 Dec;34(12):3158-67.
Jones CK, Schlosser MJ, van Zijl PC, Pomper MG, Golay X, Zhou J, Amide proton transfer imaging of human brain tumors at 3T. Magn Reson Med. 2006 Sep;56(3):585-92.
