Bioxydyn provides advanced functional MRI biomarkers in oncology, using techniques such as diffusion MRI and dynamic contrast-enhanced (DCE) MRI, and is the leading CRO offering tumor hypoxia imaging to inform therapy effectiveness or characterise tumour physiology.
We are world-leading in the use of Oxygen-enhanced MRI (OE-MRI), which can be applied to monitor the delivery of oxygen to tumours. This is of particular utility, as tumour oxygenation levels are known to impact on disease progression and on response to therapy. Our method for identifying and imaging tumour hypoxia has been shown to be sensitive to drug and radiotherapy effects. Bioxydyn personnel lead the field in developing and deploying OE-MRI.
Dynamic contrast-enhanced MRI (DCE-MRI) is recognised by the Quantitative Imaging Biomarkers Alliance (QIBA) as a functional imaging biomarker of angiogenesis and vascular function in cancer. Bioxydyn personnel bring decades of experience to the study of cancer using DCE-MRI.
Diffusion MRI (apparent diffusion coefficient, ADC) detects changes in water diffusion, which is a sensitive marker for cancer. These changes are typically associated with the earliest stages of biological response to treatment and so can act as early markers of the influence of intervention.
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Little RA, Barjat H, Hare JI, Jenner M, Watson Y, Cheung S, Holliday K, Zhang W, O'Connor JPB, Barry ST, Puri S, Parker GJM, Waterton JC, Evaluation of dynamic contrast-enhanced MRI biomarkers for stratified cancer medicine: How do permeability and perfusion vary between human tumours? Magn Reson Imaging. 2018 Feb;46:98-105.
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