Bioxydyn offers MRI measurement of liver transporter fluxes using dynamic contrast-enhanced MRI (DCE-MRI), plus other imaging biomarkers, including relaxation time measurements, in the investigation of liver diseases.
Bioxydyn is the lead commercial partner in the IMI TRISTAN project, which is investigating the liver and lung toxicity of many drugs in use today with the goal of validating the use of imaging biomarkers to assess and predict the toxicity of potential medicines on the liver and lungs.
We use dynamic contrast-enhanced MRI (DCE-MRI) of gadoxetate to measure liver transporter function. We use relaxation time measurements to assess tissue status.
The image shows the repeatability of variable flip angle (VFA) T1 measurements in the healthy liver, measured at 1.5 T and 3 T. The box plots indicate the median and interquartile range (IQR), and the whiskers encompass all points within 1.5 x IQR. Each color-coded datapoint represents a single volunteer. BH = measurements in breath hold; FB = measurements during free-breathing. From Tadimalla et al 2022.
Melillo N, Scotcher D, Kenna JG, Green C, Hines CDG, Laitinen I, Hockings PD, Ogungbenro K, Gunwhy ER, Sourbron S, Waterton JC, Schuetz G, Galetin A, Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug-Drug Interactions in Rats. Pharmaceutics. 2023 Mar 10;15(3):.
Tadimalla S, Wilson DJ, Shelley D, Bainbridge G, Saysell M, Mendichovszky IA, Graves MJ, Guthrie JA, Waterton JC, Parker GJM, Sourbron SP, Bias, Repeatability and Reproducibility of Liver T(1) Mapping With Variable Flip Angles. J Magn Reson Imaging. 2022 Oct;56(4):1042-1052.
Waterton JC, Survey of water proton longitudinal relaxation in liver in vivo. MAGMA. 2021 Dec;34(6):779-789.
Berks M, Little RA, Watson Y, Cheung S, Datta A, O'Connor JPB, Scaramuzza D, Parker GJM, A model selection framework to quantify microvascular liver function in gadoxetate-enhanced MRI: Application to healthy liver, diseased tissue, and hepatocellular carcinoma. Magn Reson Med. 2021 Oct;86(4):1829-1844.
Ulloa JL, Stahl S, Yates J, Woodhouse N, Kenna JG, Jones HB, Waterton JC, Hockings PD, Assessment of gadoxetate DCE-MRI as a biomarker of hepatobiliary transporter inhibition. NMR Biomed. 2013 Oct;26(10):1258-70.
Banerji A, Naish JH, Watson Y, Jayson GC, Buonaccorsi GA, Parker GJ, DCE-MRI model selection for investigating disruption of microvascular function in livers with metastatic disease. J Magn Reson Imaging. 2012 Jan;35(1):196-203.
